Genomic characterization and infectivity of a novel SARS-like coronavirus in Chinese bats.
Identifieur interne : 000C76 ( Main/Exploration ); précédent : 000C75; suivant : 000C77Genomic characterization and infectivity of a novel SARS-like coronavirus in Chinese bats.
Auteurs : Dan Hu [République populaire de Chine] ; Changqiang Zhu [République populaire de Chine] ; Lele Ai [République populaire de Chine] ; Ting He [République populaire de Chine] ; Yi Wang [République populaire de Chine] ; Fuqiang Ye [République populaire de Chine] ; Lu Yang [République populaire de Chine] ; Chenxi Ding [République populaire de Chine] ; Xuhui Zhu [République populaire de Chine] ; Ruicheng Lv [République populaire de Chine] ; Jin Zhu [République populaire de Chine] ; Bachar Hassan [États-Unis] ; Youjun Feng [République populaire de Chine] ; Weilong Tan [République populaire de Chine] ; Changjun Wang [République populaire de Chine]Source :
- Emerging microbes & infections [ 2222-1751 ] ; 2018.
Descripteurs français
- KwdFr :
- Animaux, Cadres ouverts de lecture, Chine, Chiroptera (virologie), Coronavirus (), Coronavirus (génétique), Coronavirus (isolement et purification), Coronavirus (pathogénicité), Femelle, Génome viral, Mâle, Phylogénie, Protéines virales (), Protéines virales (génétique), Protéines virales (métabolisme), Rats, Virulence.
- MESH :
- génétique : Coronavirus, Protéines virales.
- isolement et purification : Coronavirus.
- métabolisme : Protéines virales.
- pathogénicité : Coronavirus.
- virologie : Chiroptera.
- Animaux, Cadres ouverts de lecture, Chine, Coronavirus, Femelle, Génome viral, Mâle, Phylogénie, Protéines virales, Rats, Virulence.
- Wicri :
- geographic : République populaire de Chine.
English descriptors
- KwdEn :
- Animals, China, Chiroptera (virology), Coronavirus (classification), Coronavirus (genetics), Coronavirus (isolation & purification), Coronavirus (pathogenicity), Female, Genome, Viral, Male, Open Reading Frames, Phylogeny, Rats, Viral Proteins (chemistry), Viral Proteins (genetics), Viral Proteins (metabolism), Virulence.
- MESH :
- chemical , chemistry : Viral Proteins.
- chemical , genetics : Viral Proteins.
- chemical , metabolism : Viral Proteins.
- geographic : China.
- classification : Coronavirus.
- genetics : Coronavirus.
- isolation & purification : Coronavirus.
- pathogenicity : Coronavirus.
- virology : Chiroptera.
- Animals, Female, Genome, Viral, Male, Open Reading Frames, Phylogeny, Rats, Virulence.
Abstract
SARS coronavirus (SARS-CoV), the causative agent of the large SARS outbreak in 2003, originated in bats. Many SARS-like coronaviruses (SL-CoVs) have been detected in bats, particularly those that reside in China, Europe, and Africa. To further understand the evolutionary relationship between SARS-CoV and its reservoirs, 334 bats were collected from Zhoushan city, Zhejiang province, China, between 2015 and 2017. PCR amplification of the conserved coronaviral protein RdRp detected coronaviruses in 26.65% of bats belonging to this region, and this number was influenced by seasonal changes. Full genomic analyses of the two new SL-CoVs from Zhoushan (ZXC21 and ZC45) showed that their genomes were 29,732 nucleotides (nt) and 29,802 nt in length, respectively, with 13 open reading frames (ORFs). These results revealed 81% shared nucleotide identity with human/civet SARS CoVs, which was more distant than that observed previously for bat SL-CoVs in China. Importantly, using pathogenic tests, we found that the virus can reproduce and cause disease in suckling rats, and further studies showed that the virus-like particles can be observed in the brains of suckling rats by electron microscopy. Thus, this study increased our understanding of the genetic diversity of the SL-CoVs carried by bats and also provided a new perspective to study the possibility of cross-species transmission of SL-CoVs using suckling rats as an animal model.
DOI: 10.1038/s41426-018-0155-5
PubMed: 30209269
Affiliations:
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China.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Jiangsu Institute of Parasitic Diseases, Wuxi, Jiangsu Province, 214064</wicri:regionArea><wicri:noRegion>214064</wicri:noRegion></affiliation></author><author><name sortKey="Ye, Fuqiang" sort="Ye, Fuqiang" uniqKey="Ye F" first="Fuqiang" last="Ye">Fuqiang Ye</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology, Research Institute for Medicine of Nanjing Command, Nanjing, 210002, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Epidemiology, Research Institute for Medicine of Nanjing Command, Nanjing, 210002</wicri:regionArea><wicri:noRegion>210002</wicri:noRegion></affiliation></author><author><name sortKey="Yang, Lu" sort="Yang, Lu" uniqKey="Yang L" first="Lu" last="Yang">Lu Yang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology, Research Institute for Medicine of Nanjing Command, Nanjing, 210002, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Epidemiology, Research Institute for Medicine of Nanjing Command, Nanjing, 210002</wicri:regionArea><wicri:noRegion>210002</wicri:noRegion></affiliation></author><author><name sortKey="Ding, Chenxi" sort="Ding, Chenxi" uniqKey="Ding C" first="Chenxi" last="Ding">Chenxi Ding</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology, Research Institute for Medicine of Nanjing Command, Nanjing, 210002, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Epidemiology, Research Institute for Medicine of Nanjing Command, Nanjing, 210002</wicri:regionArea><wicri:noRegion>210002</wicri:noRegion></affiliation></author><author><name sortKey="Zhu, Xuhui" sort="Zhu, Xuhui" uniqKey="Zhu X" first="Xuhui" last="Zhu">Xuhui Zhu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology, Research Institute for Medicine of Nanjing Command, Nanjing, 210002, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Epidemiology, Research Institute for Medicine of Nanjing Command, Nanjing, 210002</wicri:regionArea><wicri:noRegion>210002</wicri:noRegion></affiliation></author><author><name sortKey="Lv, Ruicheng" sort="Lv, Ruicheng" uniqKey="Lv R" first="Ruicheng" last="Lv">Ruicheng Lv</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology, Research Institute for Medicine of Nanjing Command, Nanjing, 210002, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Epidemiology, Research Institute for Medicine of Nanjing Command, Nanjing, 210002</wicri:regionArea><wicri:noRegion>210002</wicri:noRegion></affiliation></author><author><name sortKey="Zhu, Jin" sort="Zhu, Jin" uniqKey="Zhu J" first="Jin" last="Zhu">Jin Zhu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology, Research Institute for Medicine of Nanjing Command, Nanjing, 210002, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Epidemiology, Research Institute for Medicine of Nanjing Command, Nanjing, 210002</wicri:regionArea><wicri:noRegion>210002</wicri:noRegion></affiliation></author><author><name sortKey="Hassan, Bachar" sort="Hassan, Bachar" uniqKey="Hassan B" first="Bachar" last="Hassan">Bachar Hassan</name><affiliation wicri:level="1"><nlm:affiliation>Stony Brook University, Stony Brook, 11794, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Stony Brook University, Stony Brook, 11794</wicri:regionArea><wicri:noRegion>11794</wicri:noRegion></affiliation></author><author><name sortKey="Feng, Youjun" sort="Feng, Youjun" uniqKey="Feng Y" first="Youjun" last="Feng">Youjun Feng</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathogen Biology & Microbiology and Department of General Intensive Care Unit of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310058, China. fengyj@zju.edu.cn.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Pathogen Biology & Microbiology and Department of General Intensive Care Unit of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310058</wicri:regionArea><wicri:noRegion>310058</wicri:noRegion></affiliation></author><author><name sortKey="Tan, Weilong" sort="Tan, Weilong" uniqKey="Tan W" first="Weilong" last="Tan">Weilong Tan</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology, Research Institute for Medicine of Nanjing Command, Nanjing, 210002, China. njcdc@163.com.</nlm:affiliation><country 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bats.</title><author><name sortKey="Hu, Dan" sort="Hu, Dan" uniqKey="Hu D" first="Dan" last="Hu">Dan Hu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology, College of Preventive Medicine, Third Military Medical University, Chongqing, 400038, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Epidemiology, College of Preventive Medicine, Third Military Medical University, Chongqing, 400038</wicri:regionArea><wicri:noRegion>400038</wicri:noRegion></affiliation></author><author><name sortKey="Zhu, Changqiang" sort="Zhu, Changqiang" uniqKey="Zhu C" first="Changqiang" last="Zhu">Changqiang Zhu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology, Research Institute for Medicine of Nanjing Command, Nanjing, 210002, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Epidemiology, Research Institute for Medicine of Nanjing Command, Nanjing, 210002</wicri:regionArea><wicri:noRegion>210002</wicri:noRegion></affiliation></author><author><name sortKey="Ai, Lele" sort="Ai, Lele" uniqKey="Ai L" first="Lele" last="Ai">Lele Ai</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology, Research Institute for Medicine of Nanjing Command, Nanjing, 210002, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Epidemiology, Research Institute for Medicine of Nanjing Command, Nanjing, 210002</wicri:regionArea><wicri:noRegion>210002</wicri:noRegion></affiliation></author><author><name sortKey="He, Ting" sort="He, Ting" uniqKey="He T" first="Ting" last="He">Ting He</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology, Research Institute for Medicine of Nanjing Command, Nanjing, 210002, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Epidemiology, Research Institute for Medicine of Nanjing Command, Nanjing, 210002</wicri:regionArea><wicri:noRegion>210002</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Yi" sort="Wang, Yi" uniqKey="Wang Y" first="Yi" last="Wang">Yi Wang</name><affiliation wicri:level="1"><nlm:affiliation>Jiangsu Institute of Parasitic Diseases, Wuxi, Jiangsu Province, 214064, P.R. China.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Jiangsu Institute of Parasitic Diseases, Wuxi, Jiangsu Province, 214064</wicri:regionArea><wicri:noRegion>214064</wicri:noRegion></affiliation></author><author><name sortKey="Ye, Fuqiang" sort="Ye, Fuqiang" uniqKey="Ye F" first="Fuqiang" last="Ye">Fuqiang Ye</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology, Research Institute for Medicine of Nanjing Command, Nanjing, 210002, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Epidemiology, Research Institute for Medicine of Nanjing Command, Nanjing, 210002</wicri:regionArea><wicri:noRegion>210002</wicri:noRegion></affiliation></author><author><name sortKey="Yang, Lu" sort="Yang, Lu" uniqKey="Yang L" first="Lu" last="Yang">Lu Yang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology, Research Institute for Medicine of Nanjing Command, Nanjing, 210002, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Epidemiology, Research Institute for Medicine of Nanjing Command, Nanjing, 210002</wicri:regionArea><wicri:noRegion>210002</wicri:noRegion></affiliation></author><author><name sortKey="Ding, Chenxi" sort="Ding, Chenxi" uniqKey="Ding C" first="Chenxi" last="Ding">Chenxi Ding</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology, Research Institute for Medicine of Nanjing Command, Nanjing, 210002, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Epidemiology, Research Institute for Medicine of Nanjing Command, Nanjing, 210002</wicri:regionArea><wicri:noRegion>210002</wicri:noRegion></affiliation></author><author><name sortKey="Zhu, Xuhui" sort="Zhu, Xuhui" uniqKey="Zhu X" first="Xuhui" last="Zhu">Xuhui Zhu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology, Research Institute for Medicine of Nanjing Command, Nanjing, 210002, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Epidemiology, Research Institute for Medicine of Nanjing Command, Nanjing, 210002</wicri:regionArea><wicri:noRegion>210002</wicri:noRegion></affiliation></author><author><name sortKey="Lv, Ruicheng" sort="Lv, Ruicheng" uniqKey="Lv R" first="Ruicheng" last="Lv">Ruicheng Lv</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology, Research Institute for Medicine of Nanjing Command, Nanjing, 210002, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Epidemiology, Research Institute for Medicine of Nanjing Command, Nanjing, 210002</wicri:regionArea><wicri:noRegion>210002</wicri:noRegion></affiliation></author><author><name sortKey="Zhu, Jin" sort="Zhu, Jin" uniqKey="Zhu J" first="Jin" last="Zhu">Jin Zhu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology, Research Institute for Medicine of Nanjing Command, Nanjing, 210002, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Epidemiology, Research Institute for Medicine of Nanjing Command, Nanjing, 210002</wicri:regionArea><wicri:noRegion>210002</wicri:noRegion></affiliation></author><author><name sortKey="Hassan, Bachar" sort="Hassan, Bachar" uniqKey="Hassan B" first="Bachar" last="Hassan">Bachar Hassan</name><affiliation wicri:level="1"><nlm:affiliation>Stony Brook University, Stony Brook, 11794, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Stony Brook University, Stony Brook, 11794</wicri:regionArea><wicri:noRegion>11794</wicri:noRegion></affiliation></author><author><name sortKey="Feng, Youjun" sort="Feng, Youjun" uniqKey="Feng Y" first="Youjun" last="Feng">Youjun Feng</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathogen Biology & Microbiology and Department of General Intensive Care Unit of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310058, China. fengyj@zju.edu.cn.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Pathogen Biology & Microbiology and Department of General Intensive Care Unit of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310058</wicri:regionArea><wicri:noRegion>310058</wicri:noRegion></affiliation></author><author><name sortKey="Tan, Weilong" sort="Tan, Weilong" uniqKey="Tan W" first="Weilong" last="Tan">Weilong Tan</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology, Research Institute for Medicine of Nanjing Command, Nanjing, 210002, China. njcdc@163.com.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Epidemiology, Research Institute for Medicine of Nanjing Command, Nanjing, 210002</wicri:regionArea><wicri:noRegion>210002</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Changjun" sort="Wang, Changjun" uniqKey="Wang C" first="Changjun" last="Wang">Changjun Wang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology, College of Preventive Medicine, Third Military Medical University, Chongqing, 400038, China. science2008@hotmail.com.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Epidemiology, College of Preventive Medicine, Third Military Medical University, Chongqing, 400038</wicri:regionArea><wicri:noRegion>400038</wicri:noRegion></affiliation></author></analytic><series><title level="j">Emerging microbes & infections</title><idno type="eISSN">2222-1751</idno><imprint><date when="2018" type="published">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>China</term><term>Chiroptera (virology)</term><term>Coronavirus (classification)</term><term>Coronavirus (genetics)</term><term>Coronavirus (isolation & purification)</term><term>Coronavirus (pathogenicity)</term><term>Female</term><term>Genome, Viral</term><term>Male</term><term>Open Reading Frames</term><term>Phylogeny</term><term>Rats</term><term>Viral Proteins (chemistry)</term><term>Viral Proteins (genetics)</term><term>Viral Proteins (metabolism)</term><term>Virulence</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Cadres ouverts de lecture</term><term>Chine</term><term>Chiroptera (virologie)</term><term>Coronavirus ()</term><term>Coronavirus (génétique)</term><term>Coronavirus (isolement et purification)</term><term>Coronavirus (pathogénicité)</term><term>Femelle</term><term>Génome viral</term><term>Mâle</term><term>Phylogénie</term><term>Protéines virales ()</term><term>Protéines virales (génétique)</term><term>Protéines virales (métabolisme)</term><term>Rats</term><term>Virulence</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Viral Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Viral Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Viral Proteins</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>China</term></keywords><keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Coronavirus</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Coronavirus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Coronavirus</term><term>Protéines virales</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Coronavirus</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Coronavirus</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Protéines virales</term></keywords><keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Coronavirus</term></keywords><keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Coronavirus</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Chiroptera</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Chiroptera</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Female</term><term>Genome, Viral</term><term>Male</term><term>Open Reading Frames</term><term>Phylogeny</term><term>Rats</term><term>Virulence</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Cadres ouverts de lecture</term><term>Chine</term><term>Coronavirus</term><term>Femelle</term><term>Génome viral</term><term>Mâle</term><term>Phylogénie</term><term>Protéines virales</term><term>Rats</term><term>Virulence</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>République populaire de Chine</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">SARS coronavirus (SARS-CoV), the causative agent of the large SARS outbreak in 2003, originated in bats. Many SARS-like coronaviruses (SL-CoVs) have been detected in bats, particularly those that reside in China, Europe, and Africa. To further understand the evolutionary relationship between SARS-CoV and its reservoirs, 334 bats were collected from Zhoushan city, Zhejiang province, China, between 2015 and 2017. PCR amplification of the conserved coronaviral protein RdRp detected coronaviruses in 26.65% of bats belonging to this region, and this number was influenced by seasonal changes. Full genomic analyses of the two new SL-CoVs from Zhoushan (ZXC21 and ZC45) showed that their genomes were 29,732 nucleotides (nt) and 29,802 nt in length, respectively, with 13 open reading frames (ORFs). These results revealed 81% shared nucleotide identity with human/civet SARS CoVs, which was more distant than that observed previously for bat SL-CoVs in China. Importantly, using pathogenic tests, we found that the virus can reproduce and cause disease in suckling rats, and further studies showed that the virus-like particles can be observed in the brains of suckling rats by electron microscopy. Thus, this study increased our understanding of the genetic diversity of the SL-CoVs carried by bats and also provided a new perspective to study the possibility of cross-species transmission of SL-CoVs using suckling rats as an animal model.</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li><li>États-Unis</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Hu, Dan" sort="Hu, Dan" uniqKey="Hu D" first="Dan" last="Hu">Dan Hu</name></noRegion><name sortKey="Ai, Lele" sort="Ai, Lele" uniqKey="Ai L" first="Lele" last="Ai">Lele Ai</name><name sortKey="Ding, Chenxi" sort="Ding, Chenxi" uniqKey="Ding C" first="Chenxi" last="Ding">Chenxi Ding</name><name sortKey="Feng, Youjun" sort="Feng, Youjun" uniqKey="Feng Y" first="Youjun" last="Feng">Youjun Feng</name><name sortKey="He, Ting" sort="He, Ting" uniqKey="He T" first="Ting" last="He">Ting He</name><name sortKey="Lv, Ruicheng" sort="Lv, Ruicheng" uniqKey="Lv R" first="Ruicheng" last="Lv">Ruicheng Lv</name><name sortKey="Tan, Weilong" sort="Tan, Weilong" uniqKey="Tan W" first="Weilong" last="Tan">Weilong Tan</name><name sortKey="Wang, Changjun" sort="Wang, Changjun" uniqKey="Wang C" first="Changjun" last="Wang">Changjun Wang</name><name sortKey="Wang, Yi" sort="Wang, Yi" uniqKey="Wang Y" first="Yi" last="Wang">Yi Wang</name><name sortKey="Yang, Lu" sort="Yang, Lu" uniqKey="Yang L" first="Lu" last="Yang">Lu Yang</name><name sortKey="Ye, Fuqiang" sort="Ye, Fuqiang" uniqKey="Ye F" first="Fuqiang" last="Ye">Fuqiang Ye</name><name sortKey="Zhu, Changqiang" sort="Zhu, Changqiang" uniqKey="Zhu C" first="Changqiang" last="Zhu">Changqiang Zhu</name><name sortKey="Zhu, Jin" sort="Zhu, Jin" uniqKey="Zhu J" first="Jin" last="Zhu">Jin Zhu</name><name sortKey="Zhu, Xuhui" sort="Zhu, Xuhui" uniqKey="Zhu X" first="Xuhui" last="Zhu">Xuhui Zhu</name></country><country name="États-Unis"><noRegion><name sortKey="Hassan, Bachar" sort="Hassan, Bachar" uniqKey="Hassan B" first="Bachar" last="Hassan">Bachar Hassan</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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